this page last modified
Causes of Childhood Cancer
This page links to information about possible environmental causes of childhood cancer and organizations that attempt to study environmental causes. Note that leukemia causes is in a separate section, linked to at the right. (Some childhood cancers, such as Wilms tumor and retinoblastoma, have a strong hereditary predilection. Genetic causes of childhood cancer are not in the scope of the links on this page.)
From the NCI (National Cancer Institute):
- 1/2002 Press Release on trends and causes: National Cancer Institute Research on Childhood Cancers
- SEER Program NCI's Surveillance, Epidemiology, and End Results (SEER) Program published in 1999.
- NCI's Current Research on Childhood Cancer.
- NCI's survivorship research efforts is the Childhood Cancer Survivor Study (CCSS)
- NCI's Fact sheet on cancer clusters
From the U of Minn Epidemiology:
Children's Cancer Research Group
The Group carries out a programme of epidemiological and follow-up studies of childhood cancer and is responsible for the National Registry of Childhood Tumours. This page has a good bibliography of papers on causes of childhood cancers (often with abstracts) and it has research notes. Mission Statement: The Childhood Cancer Research Institute (CCRI) is organized to prevent childhood cancer by investigating the root causes of this disease and educating the public on these critical findings. CCRI specializes in epidemiological studies of radiation- related causes of cancer and promoting public participation in radiation health risk assessment and management. (UK)
Environmental Health Perspectives
Carcinogen Risk Assessment Guidelines and Children, Editorial, Environmental Health Perspectives Volume 107, Number 6, June 1999. "The protection of children will require . . . that guidelines for risk assessment address children." This editorial discusses the challenges of how to adapt the proposed carcinogen risk assessment guidelines to embrace the needs of infants and children so that they will be adequately protected. It includes a detailed bibliography. By Patricia A. Buffler and Amy D. Kyle, School of Public Health, University of California Berkeley, California.
Electromagnetic fields/power lines
See the leukemia causes area on this web site.
The Radiation and Public Health Project is gathering baby teeth from children with and without cancer and studying the level of radiation in the teeth to see if there is a correlation with cancer and radiation. You can send your child's baby teeth to them if you would like to contribute to their study.
A record-based case-control study of natural background radiation and the incidence of childhood leukaemia and other cancers in Great Britain during 1980-2006. Kendall GM et al., Leukemia, epub 2012 Jun 5. Abstract. "There was 12% excess relative risk of childhood leukaemia per millisievert of cumulative red bone marrow dose from gamma radiation; the analogous association for radon was not significant . . . "
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Pearce MS et al., Lancet, epub 2012 Jun 7. Abstract.
Reduced occurrence of childhood cancer in twins compared to singletons: Protection but by what mechanism? M.F.G. Murphy et al., Pediatric Blood & Cancer Volume 51, Issue 1, pages 62–65, July 2008. Abstract.
Pesticides, soft-tissue sarcoma and non-Hodgkin lymphoma - historical aspects on the precautionary principle in cancer prevention. Lennart Hardell. Acta Oncologica, Volume 47, Issue 3 2008, pages 347-354. Abstract.
Oil combustion and childhood cancers. Knox EG. J Epidemiol Community Health. 2005 Sep;59(9):755-60. PubMed Abstract.
Childhood cancers and atmospheric carcinogens. Knox EG. J Epidemiol Community Health. 2005 Feb;59(2):101-5. PubMed Abstract.
Exposure to power-frequency magnetic fields and the risk of childhood cancer. UK Childhood Cancer Study Investigators. Lancet Volume 354 Issue 9194 Page 1925 1999. I have a pdf of this article.
Parental occupational exposures and risk of childhood cancer. Colt JS, Blair A. Environ Health Perspect 1998 Jun;106 Suppl 3:909-25. Full text is available.
Cancer in the offspring of radiation workers: a record linkage study. Draper GJ, Little MP, Sorahan T, Kinlen LJ, Bunch KJ, Conquest AJ, Kendall GM, Kneale GW, Lancashire RJ, Muirhead CR, O'Connor CM, Vincent TJ. BMJ 1997 Nov 8;315(7117):1181-8. PubMed abstract. Full Text article.
Epstein-Barr virus (EBV) may be linked to certain leukemias and lymphomas. This topic was discussed on the ped-onc email list in March 2001 (search the archives if you are a member); you can search MedLine for journal articles.
These pages are intended for informational purposes only and are not intended to render medical advice. The information provided on Ped Onc Resource Center should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you suspect your child has a health problem, you should consult your health care provider.