MRD degree

5 weeks

(end of induction)

12 weeks

beginning of consolidation

22-25 weeks

end of consolidation

28-33 weeks

end of reinduction

1 year

mid- maintenance

70 weeks

maintenance

80 weeks

maintenance

2 years

end of treatment

3 years

off treatment

number of relapses over number of total patients with the specified MRD degree at each time point

negative

2/71

14/124

18/166

28/173

14/166

10/117

10/162

9/148

4/95

positive

40/98

27/53

32/47

15/19

18/21

5/8

7/9

5/6

1/2

low (<10-4)

8/33

8/28

16/27

10/14

9/12

1/4

2/3

3/4

0/0

intermediate (10-3)

12/38

9/15

4/8

2/2

5/5

1/1

0/1

2/2

0/1

high (>10-2)

20/27

10/10

12/12

3/3

4/4

3/3

5/5

0/0

1/1