POG 9905

Phase III Randomized Study of Multidrug Delayed Intensification Therapy in Children With Newly Diagnosed Standard Risk Acute Lymphocytic Leukemia.

Note: this outline was patched together from the NCI online protocol and input from parents of kids with ALL. It is summarized here for our convenience, so that we can quickly compare our protocols. We do not guarantee the accuracy of this outline - it is not an official document. You can contact your child's oncologist and ask for the complete protocol document if you are interested in the details of your child's protocol.

This trial on the cancer.gov site.

Treatment for standard risk ALL, defined as presenting features of:


Protocol Outline

All patients receive induction therapy as per POG 9900. (weeks 1-4)


3-drug induction (vinc, asp, dex) (please double check this outline on the COG or the cancer.gov site)


After the 4-week induction:

For consolidation, patients are randomized to one of four treatment arms. Patients with t(1;19) are randomized to either arm III or arm IV.

Arm I: (weeks 5-24)

Arm II: (weeks 5-24)

Arm III: (weeks 5-32)

Arm IV: (weeks 5-32)

Intensive continuation therapy

At weeks 25-72 for arms I and II, and at weeks 33-80 for arms III and IV, patients receive intensive continuation therapy consisting of

Treatment repeats every 12 weeks for 4 courses.

Continuation therapy

At weeks 73-130 for arms I and II, and at weeks 81-130 for arms III and IV, patients receive continuation therapy consisting of:

Patients are followed monthly for 1 year, every 2 months for 1 year, every 3 months for 1 year, every 6 months for 1 year, and then every 6-12 months for 1 year.

Projected Accrual

A total of 1014 patients will be accrued for this study over 3.22 years.

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Last Updated 4/06

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