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• types of ALL: immunological characterization
• molecular characterization of ALL
• MRD: minimal residual disease
• clinical trials for ALL: intro
• relapsed ALL
• list of ALL clinical trials, past and present
• environmental causes of leukemia
• bibliography of ALL journal articles
• ALL cancer.gov link
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related pages

• leukemia
• signs of leukemia

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Acute Lymphoblastic Leukemia, ALL

Note: This section has health/medical information. It was not written by a health care professional. Please follow the link below for the medical information sources that were used as references for the entire ALL section. Individual pages in this section will list specific references as appropriate.

• Sources of the health information for this section on ALL.

This section on ALL is the most comprehensive disease section on this web site because it is the type of cancer that most interests your author. The information presented falls into several sections as outlined below.

Classification of ALL

How ALL is classified into subtypes and how it is characterized by current clinical tests:

• Types of ALL: pre-B, B, and T cell leukemias and how they determine this
• Molecular characterization of ALL: karyotypes and cytogenetics: discussion of hyper/hypodiploidy, translocations, point mutations, deletions, list of the translocations that have known prognostic factors

Treatment protocols and clinical trials

Treatment protocols and the role of clinical trials in the treatment of ALL; how patients are directed to the different available trials by the details of their disease:

• Clinical trials/protocols for ALL: background and general information about protocols and trials; prognostic factors that direct treatment; author's essay on learning about prognostic factors
• ALL trial listing: lengthy list of current/past trials and lay outlines of each

New Treatments and Treatment Directions in the Pipeline

Targeted Therapies for Childhood ALL. Article written by the author of this website, 2010.

Recently identified genetic alterations in childhood ALL and the TARGET iniative. Article written by the author of this website, 2010.

Journal articles/news releases of possible new treatments.

Relapsed ALL

Relapsed ALL is covered on (one of) the web author's other web site, all-kids.org. This special section was written in response to posts to the ALL-kids and ALL-kids-relapsed e-mail lists. Parents wanted to know what questions to ask at relapse. The answers led to the following web pages, as well as an article in the Candlelighters Spring/Summer 2007 Newsletter.

• Questions to ask at relapse
• Chemotherapy vs transplant as treatment for relapsed ALL
• Protocols for relapsed ALL, past and current (2007)
• Questions to ask the transplant team
• Bibliography of journal articles on relapsed ALL

Minimal residual disease - MRD

Probably a lot more than you want to know about MRD; you can always stop at the first page and the introduction for the basics.

• MRD pages

Environmental causes of leukemia

Who is studying the epidemiology of ALL and what they have found out.

• Environmental causes of leukemia

Bibliography

Bibliography of pertinent/interesting journal articles on ALL.

• Bibliography

Highly Recommended:

A great online video about ALL produced by Toronto Sick Kids hospital.

Links to web sites with ALL technical and research information

• NCI section on ALL on the cancer.gov site. This is so important that I have a navigation link to it on each ALL page.
• ASCO meetings, abstracts. A good place to start research into the latest treatments for ALL and relapsed ALL.
• ASH meetings, abstracts. Another good place to start research into the latest treatments for ALL and relapsed ALL.
• Childhood ALL, an article in The Oncologist by Rubnitz and Pui (1997).
• E-medicine site discussion on ALL (mostly adult ALL).
• St. Jude's cure4kids section (requires registration). Slide presentations, abstracts, more on the latest research in ALL (and other cancers).
• Also see the leukemia links on the leukemia page on this web site.

Sources of all the health information for this section on ALL.

General Disclaimer

These pages are intended for informational purposes only and are not intended to render medical advice. The information provided on Ped Onc Resource Center should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you suspect your child has a health problem, you should consult your health care provider.

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