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Acute Lymphoblastic Leukemia, ALL
Most of the information on this and linked pages was written before 2010. As we know, new discoveries in science keep happening, and some of the information will become outdated. For instance, researchers are always finding new molecular characterizations for ALL, and new treatments. Please check the "this page last modified" at the top of each page.
I do keep up the bibliographies of journal articles (last entry below), since I am still interested in how treatments for ALL are proceeding.
Classification of ALL
How ALL is classified into subtypes and how it is characterized by current clinical tests:
- Types of ALL: pre-B, B, and T cell leukemias and how they determine this
- Molecular characterization of ALL: karyotypes and cytogenetics: discussion of hyper/hypodiploidy, translocations, point mutations, deletions, list of the translocations that have known prognostic factors
Treatment protocols and clinical trials
Treatment protocols and the role of clinical trials in the treatment of ALL; how patients are directed to the different available trials by the details of their disease:
- Clinical trials/protocols for ALL: background and general information about protocols and trials; prognostic factors that direct treatment; author's essay on learning about prognostic factors
- ALL trial listing: lengthy list of current/past trials and lay outlines of each
New Treatments and Treatment Directions in the Pipeline
Targeted Therapies for Childhood ALL. Article written by the author of this website, 2010.
Recently identified genetic alterations in childhood ALL and the TARGET iniative. Article written by the author of this website, 2010.
Journal articles/news releases of possible new treatments. Last updated 12/2015.
Relapsed ALL is covered on the web author's other web site, all-kids.org. This special section was written in response to posts to the ALL-kids and ALL-kids-relapsed e-mail lists. Parents wanted to know what questions to ask at relapse.
- Questions to ask at relapse
- Chemotherapy vs transplant as treatment for relapsed ALL
- Protocols for relapsed ALL, past and current (2007)
- Questions to ask the transplant team
- Bibliography of journal articles on relapsed ALL
Minimal residual disease - MRD
Probably a lot more than you want to know about MRD; you can always stop at the first page and the introduction for the basics.
Environmental causes of leukemia
Who is studying the epidemiology of ALL and what they have found out.
Bibliography of pertinent/interesting journal articles on ALL.
- ASCO meetings, abstracts. A good place to start research into the latest treatments for ALL and relapsed ALL.
- Medscape discussion on ALL
- St. Jude's cure4kids section (requires registration). Slide presentations, abstracts, more on the latest research in ALL (and other cancers).
These pages are intended for informational purposes only and are not intended to render medical advice. The information provided on Ped Onc Resource Center should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you suspect your child has a health problem, you should consult your health care provider.
© copyright 1998-2018 by Patty Feist